Read&Write for Windows can be licenced within a VDI setup, such as where users hot desk or when VDI sessions are non-persistent.
There are a couple of ways to set up this up:
For a Single User license the license file is stored and persisted in the user settings folder (appdata folder), this will follow the user if the settings are Roaming.
For Group/Unlimited licences there should not be an issue for storing the license, either the license file is saved to user settings (appdata folder) or using the Multi-User Setup Tool a specific location can be selected to store this file. The other requirements here are using the Multi-User Setup Tool for rolling out the Product Code on the VM's and ability for Read&Write to see the domain for WFH users.